Published Models

Guidance-by-followers combined with one of several simple rule sets for integration of signals from multiple neighbors provides a robust mechanism for collective cell migration. Introduction Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor invasion.

Introduction Whether individual stem cell divisions are coordinated or random is important for tissue morphogenesis, homeostasis and tumour growth. Lupperger et al. have analyzed the spatio-temporal division patterns of adult neural stem cells (NSC) in the zebrafish telencephalon.

Spatio-temporal model of self-organisation inside the zebrafish posterior lateral line primordium Introduction The zebrafish posterior lateral line primordium is the precursor of the neuromasts, which form sensory organs responding to fluid flow.

The migration of zebrafish polster cells is oriented by the migration of follower cells, allowing robust long-range coordination of different cell populations. Introduction Collective cell migration is an important process during biological development and tissue repair.

Spatio-temporal model of BMP signaling Introduction Juxtaposed sources of bone morphogenetic protein (BMP) and Nodal signaling molecules induce the formation of a full body axis in zebrafish embryos. Soh et al.

Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4C of the referenced paper. Parameter values correspond to the wild type pattern (control) as given in Table S2 of the referenced paper.

Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4D of the referenced paper. Parameter values correspond to the β-catenin-1(RNAi) pattern as given in Table S2 of the referenced paper.

Introduction Larvae of the nematode Caenorhabditis elegans aggregate into clusters of several hundred moving individuals when starved during their first larval stage (see video below). Avery et al. proposed that starved larvae produce and respond chemotactically to two diffusible chemical signals, a short-range attractant and a longer range repellent.

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.